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Som beskrevet ovenfor kan gentleman opleve medicinoverforbrugshovedpine ved anvendelse af paracetamol i længere perioder advert gangen.De aktive stoffer buprenorphin og nalbuphin er midler der virker som de andre syntetiske opioider, men de har desuden en modsatrettet virkning, idet de også spærrer for andre opioiders virkning.Opioider anvendes